A spotlight on electrophysiological remodeling and the molecular biology of ion channels.
نویسندگان
چکیده
a , b c * Stanley Nattel , Dan M. Roden , Denis Escande Department of Medicine and Research Center, Montreal Heart Institute, Department of Medicine, University of Motreal, and Department of ́ Pharmacology, McGill University, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA Lab. Physiopath. & Pharm. Cellulaire, INSERM CJF 96-01, Hotel Dieu -4e etage, Place Alexis Ricordeau, 44093 Nantes Cedex 1, France
منابع مشابه
The Effects of Buthotus schach Scorpion Venom on Electrophysiological Properties of Magnocellular Neurons of Rat Supraoptic Nucleus
Potassium channels are trans-membrane proteins, which selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitability cells and signal transduction pathways. Bothutous Schach (BS) scorpion venom consists of several polypeptides that could modulate ion channels. In this study, the effects of BS crude venom on passive and active electrophysiolo...
متن کاملThe Effects of Buthotus schach Scorpion Venom on Electrophysiological Properties of Magnocellular Neurons of Rat Supraoptic Nucleus
Potassium channels are trans-membrane proteins, which selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitability cells and signal transduction pathways. Bothutous Schach (BS) scorpion venom consists of several polypeptides that could modulate ion channels. In this study, the effects of BS crude venom on passive and active electrophysiolo...
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Introduction: It has recently been suggested that the KATP channel subunits Kir6.x and BKCa channels exist in the endoplasmic reticulum of cardiomyocytes and neurons. Our previous studies showed the electrophysiological behavior of cation channels in the rough endoplasmic reticulum (RER) of rat hepatocytes. Therefore, we hypothesized that KATP channels and Ca2+-activated potassium channels m...
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Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
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Introduction: Anethole is the main constituent of Pimpinella anisum L. (anise), a herbaceous annual plant which has several therapeutic effects. In the folk medicine, anise is employed as an antiepileptic drug. Specifically, this study was focused on the cellular effect of anethole, an aromatic compound in essential oils from anise and camphor. Anethole has various physiological effects on t...
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عنوان ژورنال:
- Cardiovascular research
دوره 42 2 شماره
صفحات -
تاریخ انتشار 1999